definitely annoying
Crashes / Fires:
0 / 0
Injuries / Deaths:
0 / 0
Average Mileage:
20,596 miles

About These NHTSA Complaints:

This data is from the NHTSA — the US gov't agency tasked with vehicle safety. Complaints are spread across multiple & redundant categories, & are not organized by problem.

So how do you find out what problems are occurring? For this NHTSA complaint data, the only way is to read through the comments below. Any duplicates or errors? It's not us.

2006 Mercedes-Benz E350 transmission problems

transmission problem

Find something helpful? Spread the word.
Get notified about new defects, investigations, recalls & lawsuits for the 2006 Mercedes-Benz E350:

Unsubscribe any time. We don't sell/share your email.

2006 Mercedes-Benz E350 Owner Comments

problem #8

Dec 052010


  • 70,000 miles


I have had my Mercedes E350 for about 6 months. I purchased used and the car currently has 70,000 miles on it. I got a check engine light and have taken the car to 3 mechanics. The fault codes come up as P00017 and P00018. They are telling me I need to remove the engine and rebuild the camshaft (estimated cost $5,000 -$6,000). I have researched this on line and found many other people with this same vehicle that have had the same result. I have spoken with my local Mercedes dealer and they are aware of the problem but offer no assistance to repair.

- Greensboro, GA, USA

problem #7

Aug 242010


  • 41,474 miles
2006 E Mercedes Benz at random, in an attempt to accelerate after slowing down or stoppin the vehicle will not accelerate to sufficient speed. Mercedes Benz has not been able to locate the problem. This has presented a danger for others and myself on several occasions.

- San Diego, CA, USA

problem #6

Sep 032008


  • 21,400 miles
The transmission (7 speed) in my Mercedes E350 wagon experienced a "valve body" failure that disables all steering boost, brake boost, ABS system, esp systems and transmission control. This failure if it occurs during travel will make in almost impossible to steer or brake or control the transmission. The electronic brake and stability controls systems fail. The failure of my vehicle occurred while stopped but, had I been in travel I would not have had much control and would not have been able to respond to normal traffic conditions in a safe way.

- Riverside, CA, USA

problem #5

Feb 252008

E350 6-cyl

  • Automatic transmission
  • 2,000 miles


I had my car maybe 2 months before I started having problems transmission first they said a transmission module was burned out and it had a recall I took it back several times I wasn't notified of this issue but kept having it. (park place dallas) then I took it to austin they worked on it several times same issue now Nov the issue was so bad I was going down the street 25 mph couldn't go any faster and when they picked up the car they said they couldn't find it but a solenoid switch had burned out I thought it was the heater they said it was a recall on this part also 3 weeks later burning again dragging again when driving they said the solenoid switch recalled again. They kept the car until 2/25/2008 since christmas eve. I called corporate and they had a rep who contacted Mercedes of georgetown, tx their resolution was for me to pay another 15-20 thousand dollars and they would give me a new vehicle. I called an attorney who said they could switch VIN numbers with my lender and replace this junk that I am driving. I came to Mercedes looking for a dependable car gave them $20,000 down on a $58,000 car thinking that for at least 7 to 8 years for this price I would have a dependable car this car is junk why must I continue to add on to my payment due to their mess every item recalled has been recalled at least 2 times it's also not fair they didn't notify other buyers what will they do when they no longer have warranties.

- Killeen, TX, USA

problem #4

Jul 182007

E350 6-cyl

  • Automatic transmission
  • 27,623 miles
My Mercedes Benz E-350 has intermittently experienced problems with its 7-speed transmission. The transmission locks up in a high gear and will not shift either automatically or manually. The only way to clear the problem is to turn off the engine and restart. Twice in the last week it has resulted in near collisions. Dealer fix of topping off transmission fluid and resetting the computer doesn't solve problem.

- Rolling Hills Estates, CA, USA

problem #3

Oct 042005

E350 6-cyl

  • Automatic transmission
  • 412 miles
Automatic transmission is malfunctioning, fairly consistent at low speeds.

- Naples, FL, USA

problem #2

Sep 112005

E350 6-cyl

  • Automatic transmission
  • 1,195 miles
I purchased a 2006 Mercedes E350 in August 13 and today with 1175 miles on the odometer; the transmission failed. I was driving about 30 mph and all of a sudden; the engine high revved like it went into neutral. The vehicle was stuttering like the clutch was slipping (the car is a automatic) and was barely moving; I pulled off to the side and contacted sos system. There was no check engine failures on the obc.

- Renton, WA, USA

problem #1

Jul 262005

E350 6-cyl

  • Automatic transmission
  • 662 miles
Transmission failed on 07-26-2005 left me stranded on street in hillside NJ car had to be towed to dealership. They indicated it was a computer problem malfunction and replaced computer. Transmission still having slipping occasionally svc dept said they find nothing wrong. Mb ignoring my request for a new car.

- Scotch Plains, NJ, USA

Not what you are looking for?