Some 2021 F-150 vehicles equipped with a 3.5L PowerBoost engine may experience diagnostic trouble code (DTC) U0288 stored in the secondary on-board diagnostic module C (SOBDMC), also referred to as the inverter system controller (ISC). This may be due to various software parameters within the SOBDMC. To correct the condition, follow the Service Procedure to perform a multi-module reprogramming, beginning with the powertrain control module (PCM).
